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Estradiol is an estrogen, or an agonist of the estrogen receptors (ERs), the ERα Tooltip estrogen receptor alpha and ERβ Tooltip estrogen receptor beta. [11] It is also an agonist of membrane estrogen receptors (mERs), including the GPER Tooltip G protein-coupled estrogen receptor , G q -mER Tooltip Gq-coupled membrane estrogen receptor , ER ...
It contains ethinylestradiol, an estrogen, and etonogestrel, a progestin. [4] It is used by insertion into the vagina. [3] Pregnancy occurs in about 0.3% of women with perfect use and 9% of women with typical use. [5] Common side effects include irregular vaginal bleeding, nausea, sore breasts, vaginitis, mood changes, and headache. [6]
In particular, estrogen applied topically may have a different spectrum of side effects than when administered orally, [11] and transdermal estrogens do not affect clotting as they are absorbed directly into the systemic circulation, avoiding first-pass metabolism in the liver.
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.
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Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. [5] [6] [7] In the past, it was widely used for a variety of indications, including pregnancy support for those with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency, treatment of prostate cancer and ...
Side effects of HDE specific to men may include gynecomastia (breast development), feminization and demasculinization in general (e.g., reduced body hair, decreased muscle mass and strength, feminine changes in fat mass and distribution, and reduced penile and testicular size), and sexual dysfunction (e.g., reduced libido and erectile dysfunction).
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