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Man with myxedema or severe hypothyroidism showing an expressionless face, puffiness around the eyes and pallor Additional findings include swelling of the arms and legs and significant ascites . Woman with myxedema, Bulgaria, 1930s.
Hypothyroidism – Facial puffiness and periorbital swelling occur due to infiltration with the mucopolysaccharides hyaluronic acid and chondroitin sulfate, [4] pulling fluid into the interstitial space by osmosis. Periorbital cellulitis – An inflammation and infection of the eyelid and portions of skin around the eye.
Occasionally there may be swelling of the front part of the neck due to goiter. [3] Untreated cases of hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby or congenital iodine deficiency syndrome. [5] Worldwide, too little iodine in the diet is the most common cause of hypothyroidism.
"Cortisol face" is a viral term to describe facial swelling, allegedly caused by high levels of cortisol. Can stress cause a puffy face? Experts weigh in and debunk the condition.
Pretibial myxedema is almost always preceded by the ocular signs found in Graves' disease. [3] It usually presents itself as a waxy, discolored induration of the skin—classically described as having a so-called peau d'orange (orange peel) appearance—on the anterior aspect of the lower legs, spreading to the dorsum of the feet, or as a non-localised, non-pitting edema of the skin in the ...
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Myxedema coma is an extreme or decompensated form of hypothyroidism and while uncommon, is potentially lethal. [1] [2] [3] A person may have laboratory values identical to a "normal" hypothyroid state, but a stressful event (such as an infection, myocardial infarction, or stroke) precipitates the myxedema coma state, usually in the elderly.
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