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Guaifenesin's neurological properties first became known in the late 1940s. Guaifenesin is a centrally acting muscle relaxant used routinely in large-animal veterinary surgery. Guaifenesin is used in combination with, for example, ketamine, since guaifenesin does not provide analgesia or produce unconsciousness.
There is a risk of severe liver damage with the concurrent use of acetaminophen products and excessive alcohol use (≥3 alcoholic drinks/day depending on body weight). Acetaminophen is an active ingredient of many over-the-counter single ingredient products (e.g. to treat headache), multiple ingredient combination products as well as ...
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [12] which are the sources of its stimulant and thermogenic effects. [3]
Ephedrine works by inducing the release of norepinephrine and hence indirectly activating the α-and β-adrenergic receptors. [11] Chemically, ephedrine is a substituted amphetamine and is the (1R,2S)-enantiomer of β-hydroxy-N-methylamphetamine. [14] Ephedrine was first isolated in 1885 and came into commercial use in 1926.
The main ingredients found are guaifenesin and bromhexine hydrochloride. It is to be taken orally to provide relief from cough and congested chests due to the common cold. [ 10 ] Benadryl Dry, Tickly Cough Liquid is a cough medicine found in Australia.
A combination of theophylline, ephedrine, and hydroxyzine has been marketed under the brand name Marax among others as well. [16] [17] [18] Combinations of theophylline, ephedrine, and a barbiturate were later phased out in favor of combinations of theophylline and ephedrine alone (e.g., brand name Franol).
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