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Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase . [ 1 ] It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. [ 2 ]
632 12095 Ensembl ENSG00000242252 ENSMUSG00000074489 UniProt P02818 P54615 RefSeq (mRNA) NM_199173 NM_031368 NM_001305448 NM_001305449 NM_001305450 RefSeq (protein) NP_954642 NP_001292377 NP_001292378 NP_001292379 NP_112736 Location (UCSC) Chr 1: 156.24 – 156.24 Mb Chr 3: 88.28 – 88.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteocalcin, also known as bone gamma ...
So, for example, digoxin has a half-life (or t 1 / 2 ) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (e.g., amiodarone , elimination t 1 / 2 of about 58 days) are usually started with a loading dose to achieve their desired ...
Calcitonin can be used therapeutically for the treatment of hypercalcemia or osteoporosis. [34] In a recent clinical study, subcutaneous injections of calcitonin have reduced the incidence of fractures and reduced the decrease in bone mass in women with type 2 diabetes complicated with osteoporosis. [35]
Some diseases with symptoms of decreased bone density are osteoporosis, and rickets. Some people who experience increased bone resorption and decreased bone formation are astronauts. Due to the condition of being in a zero-gravity environment, astronauts do not need to work their musculoskeletal system as hard as when on earth. Ossification ...
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible.
In large studies, women taking bisphosphonates for osteoporosis have had unusual fractures ("bisphosphonate fractures") in the femur (thigh bone) in the shaft (diaphysis or sub-trochanteric region) of the bone, rather than at the femoral neck, which is the most common site of fracture. However, these fractures are rare (12 in 14,195 women ...
The plasma total calcium concentration is in the range of 2.2–2.6 mmol/L (9–10.5 mg/dL), and the normal ionized calcium is 1.3–1.5 mmol/L (4.5–5.6 mg/dL). [4] The amount of total calcium in the blood varies with the level of plasma albumin, the most abundant protein in plasma, and therefore the main carrier of protein-bound calcium in the blood.