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The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for ' nucleus adjacent to the septum ') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus. [1] The nucleus accumbens and the olfactory tubercle collectively form the ventral striatum.
The ventral tegmental area (VTA) (tegmentum is Latin for covering), also known as the ventral tegmental area of Tsai, [1] or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain. The VTA is the origin of the dopaminergic cell bodies of the mesocorticolimbic dopamine system and other dopamine ...
The dorsal striatum is divided into the caudate and putamen by the internal capsule while the ventral striatum is composed of the nucleus accumbens and olfactory tubercle. [ 21 ] [ 22 ] The caudate has three primary regions of connectivity, with the head of the caudate demonstrating connectivity to the prefrontal cortex, cingulate cortex and ...
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
The islands of Calleja are specifically located within the ventral and medial lining of the ventral striatum in the brain, meaning that they lie towards the front and middle of this region within the temporal lobe. The insula magna, or the major island, of these complexes is located in the medial border of the nucleus accumbens.
Putamen. Coronal section of brain through intermediate mass of third ventricle. (Putamen labeled at top.) The putamen (/ pjuˈteɪmən /; from Latin, meaning "nutshell") is a round structure located at the base of the forebrain (telencephalon). The putamen and caudate nucleus together form the dorsal striatum.
The ventral striatal MSNs play a key role in motivation, reward, reinforcement, and aversion. Dorsal and ventral medium spiny neuron subtypes (i.e., direct D1-type and indirect D2-type) are identical phenotypes, but their output connections differ. [2] [3] Confocal microscopy Z projection of medium spiny neurons (MSNs) in the mouse striatum.