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A Howell–Jolly body (marked by arrow) within an erythrocyte. A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of ...
Splenectomy patients typically have Howell-Jolly bodies [11] [12] and less commonly Heinz bodies in their blood smears. [13] Heinz bodies are usually found in cases of G6PD (Glucose-6-Phosphate Dehydrogenase) and chronic liver disease. [14] A splenectomy also results in a greatly diminished frequency of memory B cells. [15]
Under normal conditions, these nuclear remnants are removed from the blood by the spleen's filtering capabilities. Howell-Jolly bodies can be identified and quantified using a blood smear or by flow cytometry. [2] A high number of Howell-Jolly bodies is indicative of splenic hypofunction and potentially autosplenectomy.
On a blood smear, Howell-Jolly bodies may be seen within red blood cells. Primary treatment for patients with symptomatic HS has been total splenectomy, which eliminates the hemolytic process, allowing for normal hemoglobin, reticulocyte and bilirubin levels. The resultant asplenic patient is susceptible to encapsulated bacterial infections ...
The woman, Sarajane Parfitt, must undergo another operation to take out the kidney, and the removal of the spleen leaves her vulnerable to serious infections, according to medical experts.
Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis. [1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. [2] The term was coined in 1989. [2]
The family of 70-year-old William Bryan claims surgeon Thomas Shaknovsky removed his liver and not his spleen during a procedure he did not survive. Family of deceased Alabama man claims surgeon ...
Splenectomy is the surgical removal of the spleen. Autosplenectomy is where certain diseases destroy the spleen's function. Stapedectomy is the removal of ossified stapes from the ear that are then replaced by a prosthesis. Sympathectomy is the cutting of the nerves. Synovectomy is the removal of the synovial membrane of a synovial joint.