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Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
The itching is typically mild-to-moderate in intensity. It may manifest as a tingling, crawling or burning sensation, and can develop even with normal liver function tests. It does not correlate with progression of liver disease, and may even improve or disappear as the disease advances.
Blood tests are performed to rule out other causes and to confirm an elevated level of vitamin B 6 with an absence of hypophosphatasia. [ 14 ] [ 11 ] [ 12 ] [ 56 ] [ 57 ] Examination does not typically show signs of a motor deficit , dysfunction of the autonomic nervous system or impairment of the central nervous system , [ 4 ] [ 3 ] although ...
Supplements That Damage the Liver The supplements the study mentioned include: Ashwagandha , used to support the nervous and endocrine systems; improve sleep; and boost mood, energy and immune levels
The metabolic effects of liver damage associated with alcoholism may also contribute to the development of alcoholic polyneuropathy. Normal products of the liver, such as lipoic acid, may be deficient in alcoholics. This deficiency would also disrupt glycolysis and alter metabolism, transport, storage, and activation of essential nutrients.
Liver toxicity, allergic reaction, anaphylaxis [3] Kava: awa, kava-kava [4] Piper methysticum: Potentiates CNS sedatives, [3] chronic use might cause a reversible dry skin condition. [18] Khat: qat Catha edulis: Chronic liver dysfunction [3] [19] Kratom: Mitragyna speciosa: Hepatotoxicity [20] [19] Liquorice root Glycyrrhiza glabra
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