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A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .
Landers Superstore opened its first branch along Epifanio delos Santos Avenue in barangay Balintawak, Quezon City on June 22, 2016. [1] Megawide Construction Corporation was the main contractor for the construction of some of its Metro Manila branches.
Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K +. Aldosterone stimulates secretion of H + via the H+/ATPase in the intercalated cells of the cortical collecting tubules; Aldosterone upregulates expression of NCC in the distal convoluted tubule chronically and its activity acutely. [18]
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids.
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.
The first enclosed shopping mall in the metropolis was Crystal Arcade located along Escolta Street in the downtown district of Binondo. This art deco building designed by Andrés Luna de San Pedro also housed the Manila Stock Exchange and was the Philippines' first air-conditioned building inaugurated on June 1, 1932.
Major Philippine mall chains include SM Supermalls, which has over 86 shopping malls around the country, and Ayala Malls, which has 31 shopping malls nationwide. Other major mall chains include Robinsons Malls, Walter Mart malls, Gaisano Malls, Ever Gotesco Malls, and Isetann.
Lorundrostat (developmental name MLS 101) is an aldosterone synthase inhibitor developed by Mineralys Therapeutics for high blood pressure. In clinical trials as an add-on medication for people with uncontrolled hypertension, decreased renin and elevated aldosterone it significantly reduced blood pressure. Hyperkalemia occurred in some trial ...