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  2. Aldosterone - Wikipedia

    en.wikipedia.org/wiki/Aldosterone

    Anxiety increases aldosterone, [36] which must have evolved because of the time delay involved in migration of aldosterone into the cell nucleus. [38] Thus, there is an advantage to an animal's anticipating a future need from interaction with a predator, since too high a serum content of potassium has very adverse effects on nervous transmission.

  3. Mineralocorticoid receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid_receptor...

    A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .

  4. Mineralocorticoid receptor - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid_receptor

    The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids.

  5. Mineralocorticoid - Wikipedia

    en.wikipedia.org/wiki/Mineralocorticoid

    The name mineralocorticoid derives from early observations that these hormones were involved in the retention of sodium, a mineral.The primary endogenous mineralocorticoid is aldosterone, although a number of other endogenous hormones (including progesterone [1] and deoxycorticosterone) have mineralocorticoid function.

  6. 18-Hydroxycorticosterone - Wikipedia

    en.wikipedia.org/wiki/18-Hydroxycorticosterone

    It spontaneously and reversibly converts to various less polar forms and derivatives, some of which serve as precursors to aldosterone or corticosterone. Specifically, 21-hydroxy-11,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone in the presence of malate and NADP+ at pH 4.8, indicating that 18-DAL acts as a metabolic ...

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  8. YouTuber Elliot Eastman, 26, Feared Dead After Armed ... - AOL

    www.aol.com/youtuber-elliot-eastman-26-feared...

    Police in the Philippines are investigating reports that kidnapped American YouTuber Elliot Eastman has been shot dead. Eastman, 26, ...

  9. Epithelial sodium channel - Wikipedia

    en.wikipedia.org/wiki/Epithelial_sodium_channel

    The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.