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  2. Haemochromatosis type 3 - Wikipedia

    en.wikipedia.org/wiki/Haemochromatosis_type_3

    Majority of the cases of hemochromatosis are caused by mutations in the HFE (Homeostatic Iron Regulator) gene. [17] Type 3 HH is characterized by compound heterozygote mutations in both transferrin receptor 2 (TFR2) and HFE, i.e. a single mutation in each gene. HFE is located on chromosome 6 and TFR2 is located on chromosome 7.

  3. Hereditary haemochromatosis - Wikipedia

    en.wikipedia.org/wiki/Hereditary_haemochromatosis

    A study of 3,011 unrelated white Australians found that 14% were heterozygous carriers of an HFE mutation, 0.5% were homozygous for an HFE mutation, and only 0.25% of the study population had clinically relevant iron overload. Most patients who are homozygous for HFE mutations do not manifest clinically relevant haemochromatosis (see Genetics ...

  4. HFE (gene) - Wikipedia

    en.wikipedia.org/wiki/HFE_(gene)

    Human homeostatic iron regulator protein, also known as the HFE protein (High FE2+), is a transmembrane protein that in humans is encoded by the HFE gene. The HFE gene is located on short arm of chromosome 6 at location 6p22.2 [ 5 ]

  5. Hemochromatosis type 4 - Wikipedia

    en.wikipedia.org/wiki/Hemochromatosis_type_4

    Type 4 hemochromatosis is caused by mutations of the SLC40A1 gene, located on the long arm of chromosome 2, specifically at 2q32.2. The SLC40A1 gene encodes ferroportin, a protein responsible for exporting iron from cells in the intestine, liver, spleen, and kidney, as well as from reticuloendothelial macrophages and the placenta. [6] [7] More ...

  6. Compound heterozygosity - Wikipedia

    en.wikipedia.org/wiki/Compound_heterozygosity

    Clinically, most cases of hemochromatosis are found in homozygotes for the most common mutation in the HFE gene. [1] But at each gene locus associated with the disease, there is the possibility of compound heterozygosity, often caused by inheritance of two unrelated alleles, of which one is a common or classic mutation, while the other is a ...

  7. More work, same salary. How employees should respond to a ...

    www.aol.com/more-same-salary-employees-respond...

    Soon after Kay took on a new role at an e-commerce company in the fall of 2023, the responsibilities began to pile up.. Kay – who asked USA TODAY to not use her full name for fear of losing her ...

  8. Booking.com could cut jobs as part of reorganization plan - AOL

    www.aol.com/news/booking-com-parent-cut-jobs...

    The company, a unit of Booking Holdings, said in an emailed statement that it was in the early stages of the review process and no firm decision had been made. As of the end of 2023, Booking ...

  9. Hemojuvelin - Wikipedia

    en.wikipedia.org/wiki/Hemojuvelin

    Hemojuvelin (HJV), also known as repulsive guidance molecule C (RGMc) or hemochromatosis type 2 protein (HFE2), is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis.