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The smallest single base deletion mutations occur by a single base flipping in the template DNA, followed by template DNA strand slippage, within the DNA polymerase active site. [3] [4] [5] Deletions can be caused by errors in chromosomal crossover during meiosis, which causes several serious genetic diseases.
Plant diseases are diseases in plants caused by pathogens (infectious organisms) and environmental conditions (physiological factors). [1] Organisms that cause infectious disease include fungi , oomycetes , bacteria , viruses , viroids , virus -like organisms, phytoplasmas , protozoa , nematodes and parasitic plants . [ 2 ]
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child.
Consequently, the underlying pathology of diseases caused by nonsense mutations is ultimately dependent on the identity of the mutated gene, and specific location of the mutation. Examples of diseases induced by nonsense mutations include: Cystic fibrosis (caused by the G542X mutation in the cystic fibrosis transmembrane conductance regulator ...
Plant disease triangle. Epidemiology is the study of factors affecting the outbreak and spread of infectious diseases. [11] A disease triangle describes the basic factors required for plant diseases. These are the host plant, the pathogen, and the environment. Any one of these can be modified to control a disease. [12]
A disease that is caused by a loss-of-function mutation is Gitelman syndrome and cystic fibrosis. [55] Gain-of-function mutations also called activating mutations, change the gene product such that its effect gets stronger (enhanced activation) or even is superseded by a different and abnormal function.
A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a DNA or RNA sequence of an organism's genome. [1] Point mutations have a variety of effects on the downstream protein product—consequences that are moderately predictable based upon the specifics of the mutation.
Disease gene identification is a process by which scientists identify the mutant genotypes responsible for an inherited genetic disorder. Mutations in these genes can include single nucleotide substitutions, single nucleotide additions/deletions, deletion of the entire gene, and other genetic abnormalities.