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This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
The pathophysiology of polymyalgia rheumatica is not well-understood. Evidence shows that there is likely a combined genetic and environmental pathophysiology behind the disease, but concrete identification of the causes, including whether or not polymyalgia rheumatica is an autoimmune disease, remains elusive. [4]
Maintaining self-tolerance requires defense against immune reactions to autoantigens. Chronic inflammatory demyelinating polyneuropathy disrupts self-tolerance and activates autoreactive T and B cells, which are normally suppressed immune cells. This leads to the organ-specific damage typical of autoimmune disease. [19]
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Severe fatigue may come on suddenly and make it difficult to be active at all. [33] The impact of fatigue can be severe and pose more of a problem than the pain. [35] Fatigue is a complicated, multifactorial, and vexing symptom that is highly prevalent (76%) and stubbornly persistent, as evidenced by longitudinal studies over 5 years. [36]
Symptoms that are commonly associated with autoimmune diseases include: [11] fatigue. This is the most common complaint of people with autoimmune disease. [12] A 2015 US survey found that 98% of people with autoimmune diseases experienced fatigue, 89% said it was a "major issue", 68% said "fatigue is anything but normal.
The presentation of the disease varies considerably from one patient to another. [8] Generally, the symptoms include nonspecific symptoms common to connective tissue diseases such as fatigue – this is common in autoimmune diseases, and is the patient's primary concern [9] malaise; fever [10] These can be the initial presentation for some ...
Autoimmune diseases are very often treated with steroids. [3] Autoimmunity means presence of antibodies or T cells that react with self-protein and is present in all individuals, even in normal health state. It causes autoimmune diseases if self-reactivity can lead to tissue damage. [4]