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Like lidocaine, bupivacaine is an amino-amide anesthetic; the aromatic head and the hydrocarbon chain are linked by an amide bond rather than an ester as in earlier local anesthetics. As a result, the amino-amide anesthetics are more stable and less likely to cause allergic reactions.
Levobupivacaine, the S(-)-enantiomer of bupivacaine has been developed as an alternative to the racemic mixture, as it has been shown to have a lower cardiotoxicity than bupivacaine. Under European Union advice, it can be applied for minor and major surgical anaesthesia , as well as (post-operative) pain management . [ 7 ]
Lidocaine is an antiarrhythmic medication of the class Ib type. [8] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart. [11] [8] When injected near nerves, the nerves cannot conduct signals to or from the brain. [9] Lidocaine was discovered in 1946 and went on sale in 1948. [12]
lidocaine [12] [13] (lignocaine) Xylocaine 1943 (Nils Löfgren and Bengt Lundqvist) 1947 (Torsten Gordh) mepivacaine: Carbocaine, Polocaine 1956 (Ekenstam and Egner) 1957 (Dhuner) meprylcaine: Epirocain metabutoxycaine: nitracaine: Ester- Aminobenzoic orthocaine: oxetacaine (oxethazaine) oxybuprocaine: benoxinate, Novesine Paraethoxycaine [14 ...
Vaccination of dogs is the practice of animal vaccination applied to dogs. Programs in this field have contributed both to the health of dogs and to the public health . In countries where routine rabies vaccination of dogs is practiced, for example, rabies in humans is reduced to a very rare event.
Bupivacaine (Marcaine) is the local anaesthetic most commonly used, although lidocaine , tetracaine, procaine, ropivacaine, levobupivicaine, prilocaine, or cinchocaine may also be used. Commonly opioids are added to improve the block and provide post-operative pain relief, examples include morphine , fentanyl , diamorphine , and buprenorphine .
A high dose of local anesthetic, typically lidocaine or prilocaine without adrenaline, [6] is slowly injected as distally as possible into the exsanguinated limb. The veins are filled with the anesthetic, with the anesthetic setting into local tissue after approximately 6–8 minutes, after which the surgery, reduction , or manipulation of the ...
The most common combination of agents used in tumescent anesthesia is lidocaine (0.05-0.10%) and epinephrine (1 ppm). [3] [4] [5] For lidocaine, total doses of 35 mg/kg [6] and 55 mg/kg [7] have been reported as reasonably safe high-end doses, in the context of liposuction.
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