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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  4. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  5. Deep vein thrombosis - Wikipedia

    en.wikipedia.org/wiki/Deep_vein_thrombosis

    A pulmonary embolism (PE) occurs when a blood clot from a deep vein (a DVT) detaches from a vein , travels through the right side of the heart, and becomes lodged as an embolus in a pulmonary artery that supplies deoxygenated blood to the lungs for oxygenation. [28] Up to one-fourth of PE cases are thought to result in sudden death. [12]

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  7. Will it snow on Thanksgiving? Here's where cold, snow and ...

    www.aol.com/snow-thanksgiving-cold-weather...

    Howling winds, cold temperatures and even the chance of heavy snow could be in store for many Americans across the country as they gather for their Thanksgiving feasts next week. Forecasters said ...

  8. Medication package insert - Wikipedia

    en.wikipedia.org/wiki/Medication_package_insert

    In the European Union, the European Medicines Agency has jurisdiction and the relevant documents are called the "summary of product characteristics" (SPC or SmPC) and the document for end-users is called the "patient information leaflet" or "package leaflet". The SPC is not intended to give general advice about treatment of a condition but does ...

  9. Pulmonary embolism - Wikipedia

    en.wikipedia.org/wiki/Pulmonary_embolism

    The pulmonary embolism rule-out criteria (PERC) helps assess people in whom pulmonary embolism is suspected, but unlikely. Unlike the Wells score and Geneva score , which are clinical prediction rules intended to risk stratify people with suspected PE, the PERC rule is designed to rule out the risk of PE in people when the physician has already ...

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