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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    A bottle of melatonin tablets. Melatonin is also available in timed-release and in liquid forms. A prolonged-release 2 mg oral formulation of melatonin sold under the brand name Circadin is approved for use in the European Union in the short-term treatment of insomnia in people age 55 and older. [11] [29] [8]

  3. Maropitant - Wikipedia

    en.wikipedia.org/wiki/Maropitant

    Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...

  4. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

  5. N-Acetylserotonin - Wikipedia

    en.wikipedia.org/wiki/N-Acetylserotonin

    N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. [1] [2] It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.

  6. Ramelteon - Wikipedia

    en.wikipedia.org/wiki/Ramelteon

    Side effects of ramelteon include somnolence, dizziness, fatigue, nausea, exacerbated insomnia, and changes in hormone levels. [3] Ramelteon is an analogue of melatonin and is a selective agonist of the melatonin MT 1 and MT 2 receptors. [3] The half-life and duration of ramelteon are much longer than those of melatonin. [7]

  7. Bedinvetmab - Wikipedia

    en.wikipedia.org/wiki/Bedinvetmab

    Half the dogs received bedinvetmab and half the dogs received a sterile saline injection every 28 days for a total of three doses. [5] Before treatment and on various days throughout the study, owners used the Canine Brief Pain Inventory (CBPI) assessment tool to measure the severity of the dog's pain and the degree to which the pain interfered ...

  8. 5-Methoxytryptamine - Wikipedia

    en.wikipedia.org/wiki/5-Methoxytryptamine

    5-MT, in contrast to the closely related melatonin, has no affinity for the melatonin receptors. [26] [27] However, it may be converted into melatonin in the body, and hence may indirectly act as a melatonin receptor agonist. [3] [5] 5-MT shows dramatically reduced activity as a monoamine releasing agent compared to tryptamine and serotonin. [8]

  9. 6-Hydroxymelatonin - Wikipedia

    en.wikipedia.org/wiki/6-Hydroxymelatonin

    6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of melatonin. [1] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation. [2] Similar to melatonin, 6-OHM is a full agonist of the MT 1 and MT 2 receptors.

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