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The clinical relevance of these findings is unknown. [2] In clinical trials, the rate of thyroid tumors in participants treated with liraglutide was 1.3 per 1000 participant years (4 people) compared to 1.0 per 1000 participants (1 person) in comparison groups.
For instance, one Novo Nordisk-funded 2022 trial compared the weight loss effects of semaglutide with liraglutide. This trial looked at 338 non-diabetic adults who had obesity or overweight.
Semaglutide resulted in more than double the average weight loss of liraglutide (5.1% versus 2.2%). ... and Assistant Professor of clinical medicine at Weill Cornell Medicine, told Healthline.
Results from early clinical trials suggest that liraglutide, ... GLP-1 drugs have recently become popular to assist in weight loss, either through off-label use or, ...
A prodrug of DNP, HU6, has been tested in clinical trials for weight loss and fatty liver disease. [ 22 ] Fibroblast growth factor-21 receptor agonists and drugs increasing FGF-21 activity are being investigated for obesity-related diseases; they can increase energy expenditure and several have been tested in humans.
Orforglipron (LY-3502970) is an oral, non-peptide, small molecule glucagon-like peptide-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. [ 1 ] [ 2 ] It is easier to produce than current peptide GLP-1 agonists and is expected to be cheaper.
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