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Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
Fluoride is present in small amounts in plants, animals, and some natural water sources. The additional fluoride in toothpaste has beneficial effects on the formation of dental enamel and bones. Sodium fluoride (NaF) is the most common source of fluoride, but stannous fluoride (SnF 2), and sodium monofluorophosphate (Na 2 PO 3 F) are also used ...
The fluoride ion from dissolved fluoride salts inhibits dental cavities and so finds use in toothpaste and water fluoridation. Global fluorochemical sales amount to more than US$ 15 billion a year. Fluorocarbon gases are generally greenhouse gases with global-warming potentials 100 to 23,500 times that of carbon dioxide , and SF 6 has the ...
The widespread use of toothpaste and mouthwashes with added fluoride in recent decades appears to have diminished the health benefits of water fluoridation, according to a new study.
Water and food sources of fluoride include community water fluoridation, seafood, tea, and gelatin. [ 52 ] Soluble fluoride salts, of which sodium fluoride is the most common, are toxic, and have resulted in both accidental and self-inflicted deaths from acute poisoning . [ 4 ]
Fluoride toothpaste prevents about 25% of cavities in young permanent teeth, and its effectiveness is improved if higher concentrations of fluoride are used, or if the toothbrushing is supervised. Fluoride mouthwash and gel are about as effective as fluoride toothpaste; fluoride varnish prevents about 45% of cavities. [93]
U.S. standards recommend fluoride levels of 0.7 milligrams per liter of water, and the NTP’s conclusion applied to water fluorinated at 1.5 milligrams per liter and above.
Fluorine is often added to drug molecules during drug design, as even a single atom can greatly change the chemical properties of the molecule in desirable ways. Because of the considerable stability of the carbon–fluorine bond , many drugs are fluorinated to delay their metabolism , which is the chemical process in which the drugs are turned ...
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