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Hemiplegic migraine is a type of migraine headache characterized by motor weakness affecting only one side of the body, accompanied by aura. There is often an impairment in vision, speech, or sensation. It can run in the family, called familial hemiplegic migraine, or in a single individual, called sporadic hemiplegic migraine.
Familial hemiplegic migraine (FHM) is an autosomal dominant type of hemiplegic migraine that typically includes weakness of half the body which can last for hours, days, or weeks. It can be accompanied by other symptoms, such as ataxia, coma, and paralysis. Migraine attacks may be provoked by minor head trauma.
The female to male ratio of diagnosed patients can range anywhere from 1.6:1 to 2.36:1. [5] However, more recent prospective research showed an equal prevalence between females and males, with a ratio close to 1:1. [3] Symptoms may begin to appear at any age, but onset usually occurs in adulthood with a mean starting age within the thirties ...
Familial hemiplegic migraine (FHM) is migraine with a possible polygenetic cause—in fact, FHM can only be diagnosed when at least one close relative has it too. [7] The patient experiences typical migraine with aura headache either preceded or accompanied with one-sided, reversible limb weakness and/or sensory difficulties and/or speech ...
Single gene disorders that result in migraines are rare. [6] One of these is known as familial hemiplegic migraine, a type of migraine with aura, which is inherited in an autosomal dominant fashion. [7] [8] Four genes have been shown to be involved in familial hemiplegic migraine. [9] Three of these genes are involved in ion transport. [9]
Spelling's 14-year-old daughter is home and doing better after suffering stroke-like symptoms.
Sporadic hemiplegic migraine (SHM) has clinical symptoms identical to familial hemiplegic migraine (FHM) and distinct from migraine with aura. By definition the neurodeficits are supposed to be reversible. However, some cases with permanent neurological deficits have also been noted. [3]
AHC patients exhibit a wide range of symptoms in addition to hemiplegic attacks. [1] These can be further characterized as paroxysmal and non-paroxysmal symptoms. Paroxysmal symptoms are generally associated with hemiplegic attacks and may occur suddenly with hemiplegia or on their own. Paroxysmal symptoms may last for variable amounts of time.
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