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Older people are more likely to experience drowsiness from antihistamine use than younger people. [1] Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in older people. [31] [32]
The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. [4] Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in older people. [8] [9]
Senile pruritus is one of the most common conditions in the elderly or people over 65 years of age with an emerging itch that may be accompanied with changes in temperature and textural characteristics. [1] [2] [3] In the elderly, xerosis, is the most common cause for an itch due to the degradation of the skin barrier over time. [4]
Chlorphenamine produces less sedation than other first-generation antihistamines. [9] A large study on people 65 years old or older linked the development of Alzheimer's disease and other forms of dementia to the "higher cumulative" use of chlorphenamine and other first-generation antihistamines, due to their anticholinergic properties. [10]
Some forms of Benadryl are to be taken orally, while some creams and gels are to be applied to the skin. [2] Common side effects of the drug include drowsiness, dizziness, dry mouth and throat, confusion, and blurred vision. [2] In the United States and Canada, the active ingredient is diphenhydramine.
Dementia affects more than 55 million people worldwide at an estimated global cost of more than $1 trillion, and up to 70% of those people have Alzheimer’s disease. ... subgroup-specific effects ...
Diphenhydramine is a first-generation antihistamine used to treat several conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms. [19] [20] Diphenhydramine also has local anesthetic properties, and has been used as such in people allergic to common local anesthetics such as ...
Ozempic linked with lower dementia risk, nicotine use, British study finds. July 12, 2024 at 1:40 PM ... The authors also cautioned that the findings cannot be applied to people without diabetes.