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This page was last edited on 13 November 2024, at 20:11 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
JWH-030 is a research chemical which is a cannabinoid receptor agonist. [2] It has analgesic effects and is used in scientific research. [ 3 ] It is a partial agonist at CB 1 receptors , with a K i of 87 nM, making it roughly half the potency of THC . [ 4 ]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a full agonist [3] at both the CB 1 and CB 2 cannabinoid receptors. It is somewhat selective for the CB 1 subtype, with affinity at this subtype approximately 5× the affinity at CB 2 . [ 4 ]
JWH may refer to: John Wesley Hardin, an American gun-fighter from the 18th century; John W. Henry, futures trader and owner of the Boston Red Sox; John Winston Howard, former Prime Minister of Australia; JWH-133, a medication used to prevent Alzheimer's disease; John W. Huffman, creator of the JWH cannabinoids
JWH-015 is a chemical from the naphthoylindole family that acts as a subtype-selective cannabinoid agonist. Its affinity for CB 2 receptors is 13.8 nM, while its affinity for CB 1 is 383 nM, meaning that it binds almost 28 times more strongly to CB 2 than to CB 1 . [ 1 ]
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