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Thermolabile refers to a substance which is subject to decomposition or change in response to heat.This term is often used describe biochemical substances. [1]For example, many bacterial exotoxins are thermolabile and can be easily inactivated by the application of moderate heat.
Targeted temperature management (TTM), previously known as therapeutic hypothermia or protective hypothermia, is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. [1]
Sufficient stress from extreme external temperature may cause injury or death if it exceeds the ability of the body to thermoregulate. Hypothermia can set in when the core temperature drops to 35 °C (95 °F). [2] Hyperthermia can set in when the core body temperature rises above 37.5–38.3 °C (99.5–100.9 °F).
An organism's natural tolerance of heat is their basal thermotolerance. [1] Meanwhile, acquired thermotolerance is defined as an enhanced level of thermotolerance after exposure to a heat stress. [ 2 ]
Drug-induced fever is a symptom of an adverse drug reaction wherein the administration of drugs intended to help a patient causes a hypermetabolic state resulting in fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism , evoke a cellular or humoral immune response , mimic endogenous pyrogen , or ...
The latter is a relatively rare side effect of many drugs, particularly those that affect the central nervous system. Malignant hyperthermia is a rare complication of some types of general anesthesia. Hyperthermia can also be caused by a traumatic brain injury. [4] [5] [6]
The temperature reading depends on which part of the body is being measured. The typical daytime temperatures among healthy adults are as follows: Temperature in the rectum (rectal), vagina, or in the ear (tympanic) is about 37.5 °C (99.5 °F) [20] [medical citation needed] Temperature in the mouth (oral) is about 36.8 °C (98.2 °F) [12]
Siegel suggested that compensatory CRs allow the organism to maintain a normal physiological state despite the administration of a drug and that they help to explain tolerance to drugs. The conditioned compensatory response may take place only in the case of subconscious learning, as the effects of conscious expectancies may tend to be in the ...