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Folate deficiency anemia during pregnancy may give rise to the birth of low weight birth premature infants and infants with neural tube defects. [6] Not consuming enough folate can lead to folate deficiency within a few months. [1] Otherwise, causes may include increased needs as with pregnancy, and in those with shortened red blood cell ...
Prolonged deficiency of vitamin B 12 leads to irreversible nervous system damage. HIV-associated vacuolar myelopathy can present with a similar pattern of dorsal column and corticospinal tract demyelination. [citation needed] It has been thought that if someone is deficient in vitamin B 12 and folic acid, the vitamin B 12 deficiency must
If the individual has a mitochondrial disease, the FRA could be lacking adequate energy, resulting in the deficiency of folate in the brain. [12] Other causes appear to be Kearns–Sayre syndrome [5] and autoantibodies to the folate receptor. [6] [7] [8] Furthermore, secondary cerebral folate deficiency can develop in patients with other ...
For example, elevated levels of folic acid can interact with vitamin B12 deficiency to cause neurodegeneration. [122] Furthermore, folic acid and iron can interact to exacerbate malaria. [123] Folic acid is the most oxidized and stable form of folate, and can also be referred to as vitamin B 9. It rarely occurs naturally in foods, but it is the ...
There is risk that folic acid administered to those with untreated B 12 deficiency may mask anemia without solving the issue at hand in which, if left untreated, can cause lasting serious side effects that affect the nervous system and brain. [153]
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
A defect in homocysteine methyltransferase or a deficiency of B 12 may lead to a so-called "methyl-trap" of THF, in which THF converts to methyl-THF, causing a deficiency in folate. [97] Thus, a deficiency in B 12 can cause accumulation of methyl-THF, mimicking folate deficiency.
Folate deficiency (vitamin B9 deficiency) can cause glossitis, along with macrocytic anemia, thrombocytopenia, leukopenia, diarrhea, fatigue and possibly neurological signs. [7] Apart from pernicious anemia discussed above, any other cause of vitamin B12 deficiency can cause glossitis, which tends to be painful, smooth and shiny. [7]
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