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  2. Beta-ketothiolase deficiency - Wikipedia

    en.wikipedia.org/wiki/Beta-ketothiolase_deficiency

    Specifically, the enzyme is responsible for processing isoleucine, an amino acid that is part of many proteins. This enzyme also processes ketones , which are produced during the breakdown of fats. If a mutation in the ACAT1 gene reduces or eliminates the activity of this enzyme, the body is unable to process isoleucine and ketones properly.

  3. Cerebral hypoxia - Wikipedia

    en.wikipedia.org/wiki/Cerebral_hypoxia

    However, if blood flow cannot be increased or if doubled blood flow does not correct the problem, symptoms of cerebral hypoxia will begin to appear. Mild symptoms include difficulties with complex learning tasks and reductions in short-term memory. If oxygen deprivation continues, cognitive disturbances, and decreased motor control will result. [6]

  4. Isoleucine - Wikipedia

    en.wikipedia.org/wiki/Isoleucine

    Isoleucine (symbol Ile or I) [1] is an α-amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated −NH + 3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO − form under biological conditions), and a hydrocarbon side chain with a branch (a central carbon atom bound to three other ...

  5. Organic acidemia - Wikipedia

    en.wikipedia.org/wiki/Organic_acidemia

    Organic acidemia is a term used to classify a group of metabolic disorders which disrupt normal amino acid metabolism, particularly branched-chain amino acids, causing a buildup of acids which are usually not present. [1] The branched-chain amino acids include isoleucine, leucine and valine. [1]

  6. Hypoxia (medicine) - Wikipedia

    en.wikipedia.org/wiki/Hypoxia_(medicine)

    The use of the term hypoxia appears to be relatively recent, with the first recorded use in scientific publication from 1945. Previous to this the term anoxia was extensively used for all levels of oxygen deprivation. Investigation into the effects of lack of oxygen date from the mid 19th century.

  7. Brain ischemia - Wikipedia

    en.wikipedia.org/wiki/Brain_ischemia

    Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population.

  8. Generalized hypoxia - Wikipedia

    en.wikipedia.org/wiki/Generalized_hypoxia

    Generalized hypoxia is a medical condition in which the tissues of the body are deprived of the necessary levels of oxygen due to an insufficient supply of oxygen, which may be due to the composition or pressure of the breathing gas, decreased lung ventilation, or respiratory disease, any of which may cause a lower than normal oxygen content in the arterial blood, and consequently a reduced ...

  9. Hypopituitarism - Wikipedia

    en.wikipedia.org/wiki/Hypopituitarism

    The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of the abnormality. The diagnosis of hypopituitarism is made by blood tests , but often specific scans and other investigations are needed to find the underlying cause, such as tumors of the pituitary, and the ideal treatment.