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Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Codeine is marketed as both a single-ingredient drug and in combination preparations with paracetamol (as co-codamol: e.g., brands Paracod, Panadeine, and the Tylenol-with-codeine series, including Tylenol 3 and 1, 2, and 4); with aspirin (as co-codaprin); or with ibuprofen (as Nurofen Plus).
In the United States, it is a schedule II controlled substance. [1] In 2022, it was the 23rd most commonly prescribed medication in the United States, with more than 23 million prescriptions. [7] [8] It is not available in the United Kingdom, [9] though the combination codeine/paracetamol (co-codamol) is. [10]
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1998 advertisement. Solpadeine is the brand name of a range of analgesic medication containing various amounts of paracetamol, ibuprofen, caffeine and codeine, made by Omega Pharma. [1]
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Intravenous paracetamol is sold under the brand name Ofirmev in the United States. [175] In some formulations, paracetamol is combined with the opiate codeine, sometimes referred to as co-codamol and Panadeine in Australia. In the U.S., this combination is available only by prescription. [176]