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Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), [5] is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).
OPN may stand for: . Osteopontin, a glycoprotein secreted by osteoblasts; Object Process Network, a simulation model meta-language; Optics & Photonics News, a magazine; Oneohtrix Point Never, recording alias of musician Daniel Lopatin
In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as ...
Minor, but important, amounts of small proteins, including osteocalcin and osteopontin, are secreted in bone's organic matrix. [21] Osteocalcin is not expressed at significant concentrations except in bone, and thus osteocalcin is a specific marker for bone matrix synthesis. [ 22 ]
The interface is filled with non-collagenous proteins, mainly osteopontin (OPN) and osteocalcin (OC). [1] The osteopontin and osteocalcin form a sandwich structure with HAP minerals at nano-scale. The nano Interfaces are less than 2 – 3 % of bone content by weight, while they add more than 30% of the fracture toughness .
11433 Ensembl ENSG00000102575 ENSMUSG00000001348 UniProt P13686 Q05117 RefSeq (mRNA) NM_001111034 NM_001111035 NM_001111036 NM_001611 NM_001322023 NM_001102404 NM_001102405 NM_007388 RefSeq (protein) NP_001104504 NP_001104505 NP_001104506 NP_001308952 NP_001602 NP_001095874 NP_001095875 NP_031414 Location (UCSC) Chr 19: 11.57 – 11.58 Mb Chr 9: 22.04 – 22.05 Mb PubMed search Wikidata View ...
Type I collagen composes 90–95% of the organic matrix, with the remainder of the matrix being a homogenous liquid called ground substance consisting of proteoglycans such as hyaluronic acid and chondroitin sulfate, [29] as well as non-collagenous proteins such as osteocalcin, osteopontin or bone sialoprotein. Collagen consists of strands of ...
osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. [3]