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Factors that affect distribution [ edit ] There are many factors that affect a drug's distribution throughout an organism, but Pascuzzo [ 1 ] considers that the most important ones are the following: an organism's physical volume, the removal rate and the degree to which a drug binds with plasma proteins and / or tissues.
A V D greater than the total volume of body water (approximately 42 liters in humans [5]) is possible, and would indicate that the drug is highly distributed into tissue. In other words, the volume of distribution is smaller in the drug staying in the plasma than that of a drug that is widely distributed in tissues. [6]
Volume of distribution: The apparent volume in which a drug is distributed (i.e., the parameter relating drug concentration in plasma to drug amount in the body). 6.0 L Concentration: Amount of drug in a given volume of plasma.
Distribution is defined as the reversible transfer of a drug between one compartment to another. Some factors affecting drug distribution include regional blood flow rates, molecular size, polarity and binding to serum proteins, forming a complex. Distribution can be a serious problem at some natural barriers like the blood–brain barrier.
Only the unbound fraction of the drug undergoes metabolism in the liver and other tissues. As the drug dissociates from the protein, more and more drug undergoes metabolism. Changes in the levels of free drug change the volume of distribution because free drug may distribute into the tissues leading to a decrease in plasma concentration profile.
A pair of Saturday NFL games drew a larger viewing audience than college football for the rollout of the sport's 12-team playoff. The playoff game between SMU and Penn State averaged 6.4 million ...
Calculation of the initial volume of distribution is the same calculation as that for the apparent volume of distribution, given by the equation: V D = t o t a l a m o u n t o f d r u g i n t h e b o d y p e r b o d y w e i g h t u n i t ( K g ) ( i . e .
This is the perfect time of year—at least here in Boston, where it is still so cold!—to tuck into a comforting bowl of soup. This one is packed with so many healthy ingredients.