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Galactokinase is composed of two domains separated by a large cleft. The two regions are known as the N- and C-terminal domains, and the adenine ring of ATP binds in a hydrophobic pocket located at their interface.
Galactokinase deficiency has an autosomal recessive pattern of inheritance.. Galactokinase deficiency is an autosomal recessive disorder, [5] which means the defective gene responsible for the disorder is located on an autosome (chromosome 17 is an autosome).
A cataract is an opacity that develops in the crystalline lens of the eye. [9] The word cataract literally means, "curtain of water" or "waterfall" as rapidly running water turns white, so the term may have been used metaphorically to describe the similar appearance between mature ocular opacities and water fall.
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GalK encodes for a kinase that phosphorylates α-D-galactose to galactose 1-phosphate. [6] Lastly, galM catalyzes the conversion of β-D-galactose to α-D-galactose as the first step in galactose metabolism. [7] The gal operon contains two operators, O E (for external) and O I (for internal).
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