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Histopathology of localized TGCT arising in hand finger. H&E stain. Localized TGCT is sometimes referred to as localized pigmented villonodular synovitis (L-PVNS), giant cell tumor of the tendon sheath (GCT-TS), nodular tenosynovitis, localized nodular tenosynovitis, and L-TGCT. [2]: 1 [3]: 100 The localized form of TGCT is more common.
Trigger finger, also known as stenosing tenosynovitis, is a disorder characterized by catching or locking of the involved finger in full or near full flexion, typically with force. [2] There may be tenderness in the palm of the hand near the last skin crease (distal palmar crease ). [ 3 ]
Infectious tenosynovitis in 2.5% to 9.4% of all hand infections. Kanavel's cardinal signs are used to diagnose infectious tenosynovitis. They are: tenderness to touch along the flexor aspect of the finger, fusiform enlargement of the affected finger, the finger being held in slight flexion at rest, and severe pain with passive extension.
A localized disease is an infectious or neoplastic process that originates in and is confined to one organ system or general area in the body, [1] such as a sprained ankle, a boil on the hand, an abscess of finger. A localized cancer that has not extended beyond the margins of the organ involved can also be described as localized disease, while ...
Local gigantism affecting second toe of a child. Local gigantism or localised gigantism is a condition in which a certain part of the body acquires larger than normal size due to excessive growth of the anatomical structures or abnormal accumulation of substances.
NOTE: I am proposing this edit for FleishmanHillard on behalf of Daiichi Sankyo.I am a paid editor and am aware of the COI guidelines. I am submitting this edit request to bring your attention to the fact that the World Health Organization reclassified pigmented villonodular synovitis (PVNS) and giant-cell tumor of the tendon sheath (GCT-TS) to “tenosynovial giant cell tumor” or “TGCT ...
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Emactuzumab [1] (RG-7155) is a humanized monoclonal antibody directed against colony stimulating factor 1 receptor (CSF-1R) expressed on macrophages [2] [3] and has demonstrated a profound antitumor effect through interference with the CSF-1/CSF-1R axis, along with a manageable safety profile in patients with diffuse-type tenosynovial giant cell tumors (d-TGCT).