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  2. Amitriptyline - Wikipedia

    en.wikipedia.org/wiki/Amitriptyline

    Blood levels of amitriptyline vary significantly from one person to another, [17] and amitriptyline interacts with many other medications potentially aggravating its side effects. Amitriptyline was discovered in the late 1950s by scientists at Merck and approved by the US Food and Drug Administration (FDA) in 1961. [ 18 ]

  3. Management of hypertension - Wikipedia

    en.wikipedia.org/wiki/Management_of_hypertension

    For most people, recommendations are to reduce blood pressure to less than or equal to somewhere between 140/90 mmHg and 160/100 mmHg. [2] In general, for people with elevated blood pressure, attempting to achieve lower levels of blood pressure than the recommended 140/90 mmHg will create more harm than benefits, [3] in particular for older people. [4]

  4. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    The TCAs such as imipramine and amitriptyline typically prevent the reuptake of serotonin or norepinephine. It is the histaminiergic (H 1), muscarinic acetylcholinergic (M 1), and alpha adrenergic (α 1) blockade that is responsible for the side-effects of TCAs. These include somnolence and lethargy, anticholinergic side-effects, and hypotension.

  5. Comparison of international blood pressure guidelines

    en.wikipedia.org/wiki/Comparison_of...

    Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )

  6. What is a normal blood pressure reading? - AOL

    www.aol.com/lifestyle/normal-blood-pressure...

    "Your blood pressure is supposed to be under 140 over 90, optimally closer to 120 over 80."

  7. Your Guide to the 6 Most Common Types of Depression ... - AOL

    www.aol.com/6-types-depression-medications...

    Medications for Depression: An Overview. Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used ...

  8. Tricyclic antidepressant - Wikipedia

    en.wikipedia.org/wiki/Tricyclic_antidepressant

    Side effects may also be less troublesome if treatment is initiated with low doses and then gradually increased, although this may also delay the beneficial effects. TCAs can behave like class 1A antiarrhythmics , as such, they can theoretically terminate ventricular fibrillation, decrease cardiac contractility and increase collateral blood ...

  9. Antihypertensive - Wikipedia

    en.wikipedia.org/wiki/Antihypertensive

    Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a chlorthalidone dose of 12.5 mg was used, with titration up to 25 mg for those subjects who did not achieve blood pressure control at 12.5 mg. Chlorthalidone has repeatedly been found to have a stronger ...

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