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Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB. The medical standard for active TB is a short course treatment involving a combination of isoniazid , rifampicin (also known as Rifampin), pyrazinamide , and ethambutol for the first two months.
Pretomanid is an antibiotic medication used for the treatment of multi-drug-resistant tuberculosis affecting the lungs. [4] [5] It is generally used together with bedaquiline and linezolid. [4] It is taken by mouth. [4] The most common side effects include nerve damage, acne, vomiting, headache, low blood sugar, diarrhea, and liver inflammation ...
Isoniazid can be used alone or in combination with Rifampin for treatment of latent tuberculosis, or as part of a four-drug regimen for treatment of active tuberculosis. [18] The drug regimen typically requires daily or weekly oral administration for a period of three to nine months, often under Directly Observed Therapy (DOT) supervision. [18]
Bedaquiline, sold under the brand name Sirturo, is a medication used for the treatment of active tuberculosis. [1] Specifically, it is used to treat multi-drug-resistant tuberculosis along with other medications for tuberculosis. [1] [8] [9] It is taken by mouth. [3] Common side effects include nausea, joint pains, headaches, and chest pain. [1]
For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. [3] It is not generally recommended for the treatment of latent tuberculosis. [2] It is taken by mouth. [1] Common side effects include nausea, loss of appetite, muscle and joint pains, and rash.
The principles of treatment for MDR-TB and for XDR-TB are the same. Second-line drugs are more toxic than the standard anti-TB regimen and can cause a range of serious side-effects including hepatitis, depression, hallucinations, and deafness. [14] Patients are often hospitalized for long periods, in isolation.
Common side effects include headache, dizziness, and nausea. [3] Other side effects include QT prolongation. [2] Use in pregnancy has not been extensively studied, but there have been reports of success [9] and it is currently recommended as part of the standard treatment regimen for pregnant women with rifampicin-resistant tuberculosis in South Africa.
There is some efficacy for linezolid to treat those with XDR-TB but side effects and discontinuation of medications were common. [160] [161] Bedaquiline is tentatively supported for use in multiple drug-resistant TB. [162] XDR-TB is a term sometimes used to define extensively resistant TB, and constitutes one in ten cases of MDR-TB. Cases of ...