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Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis. [1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. [2] The term was coined in 1989. [2]
Inclusion bodies are aggregates of specific types of protein found in neurons, and a number of tissue cells including red blood cells, bacteria, viruses, and plants. Inclusion bodies of aggregations of multiple proteins are also found in muscle cells affected by inclusion body myositis and hereditary inclusion body myopathy. [1]
Myeloblast with an Auer rod (to the left of the nucleus).. Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, high-grade myelodysplastic syndromes and myeloproliferative disorders.
Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1–3 μm in diameter. They measure 1–3 μm in diameter. Not much is known about their formation, but they are thought to be remnants of the rough endoplasmic reticulum .
Microscopic examination of liver tissue in patients with critical green inclusions has demonstrated prominent deposition of lipofuscin, suggesting that the white blood cell inclusions represent phagocytosis of this substance following severe injury to the liver. [3] [9]
An excess of white blood cells is usually due to infection or inflammation. Less commonly, a high white blood cell count could indicate certain blood cancers or bone marrow disorders. The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important subset of the complete blood count.
Mott cells with Russell bodies (red arrows), compared to an almost normal plasma cell (white arrow; it has a prominent nucleolus). Plasmacytoma with abundant Russell bodies. H&E stain. Dutcher and Russell bodies. H&E stain. Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. [1]
Jordans' anomaly (also known as Jordan anomaly and Jordans bodies) is a familial abnormality of white blood cell morphology. Individuals with this condition exhibit persistent vacuolation of granulocytes and monocytes in the peripheral blood and bone marrow. Jordans' anomaly is associated with neutral lipid storage diseases. [1] [2] [3]