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Until about 2010, [11] quinine was often recommended as a relief for leg cramps, although medical research suggested some care was needed in monitoring doses. [12] Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps. [13]
The FDA is also cautioning consumers about off-label use of quinine to treat leg cramps. [19] [20] Quinine is approved for treatment of malaria, but was also commonly prescribed to treat leg cramps and similar conditions. Because malaria is life-threatening, the risks associated with quinine use are considered acceptable when used to treat that ...
Cultural expectations play an important role in treatment as a 1985 study amongst the Mende people of Sierra Leone showed that treatment decisions were made "largely on traditional notions of the efficacy of a medicine of a particular color, consistency, taste, size and reputed success in treating analogous illnesses". [53]
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