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Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). The Cycle gene ( c yc) is expressed in a variety of cell types in a circadian manner. It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism.
Fig. 1 The diagram shows the role of Cdk1 in progression through the S. cerevisiae cell cycle. Cln3-Cdk1 leads to Cln1,2-Cdk1 activity, eventually resulting in Clb5,6-Cdk1 activity and then Clb1-4-Cdk1 activity. [5] When bound to its cyclin partners, Cdk1 phosphorylation leads to cell cycle progression.
CHEK2 regulates cell cycle progression and spindle assembly during mouse oocyte maturation and early embryo development. [ 13 ] [ 14 ] Although CHEK2 is a down stream effector of the ATM kinase that responds primarily to double-strand breaks it can also be activated by ATR (ataxia-telangiectasia and Rad3 related) kinase that responds primarily ...
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like ...
67177 Ensembl ENSG00000167513 ENSMUSG00000006585 UniProt Q9H211 Q8R4E9 RefSeq (mRNA) NM_030928 NM_026014 RefSeq (protein) NP_112190 NP_080290 Location (UCSC) Chr 16: 88.8 – 88.81 Mb Chr 8: 123.29 – 123.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a licensing ...
This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this ...
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
904 12455 Ensembl ENSG00000129315 ENSMUSG00000011960 UniProt O60563 Q9QWV9 RefSeq (mRNA) NM_001240 NM_001277842 NM_009833 NM_001368702 RefSeq (protein) NP_001231 NP_001264771 NP_033963 NP_001355631 Location (UCSC) Chr 12: 48.69 – 48.72 Mb Chr 15: 98.44 – 98.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene ...