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ER-positive is one of the Receptor statuses identified in the classification of breast cancer.Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches look at these together, along with the tumor grade, to categorize breast cancer into several conceptual molecular classes [1] that have different prognoses [2] and may have ...
Cells with none of these receptors are called basal-like or triple negative. HER2-low has some HER2 proteins on the cell surface, but not enough to be classified as HER2-positive. [4] Trastuzumab deruxtecan is the first approved therapy by the US Food and Drug Administration (FDA) targeted to people with the HER2-low breast cancer subtype. [4]
In addition to grading, tumor biopsy samples are tested by immunohistochemistry to determine if the tissue contains the proteins estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2). [48] Tumors containing either ER or PR are called "hormone receptor-positive" and can be treated with hormone ...
It has been found that patients with ER+ (Estrogen receptor positive)/HER2+ compared with ER-/HER2+ breast cancers may actually benefit more from drugs that inhibit the PI3K/AKT molecular pathway. [37] Over-expression of HER2 can also be suppressed by the amplification of other genes.
HER2-enriched (ER/PR negative; HER2 positive) Basal like (triple negative). [6] Additionally, cancers can be ER-/PR+ or ER+/PR-, but these are unnamed and relatively rare. [7] The receptor status of a cancer is assessed for all breast cancers as it has important implications on prognosis of the patient. It also dictates the treatment given ...
Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name triple-negative). [1]
Luminal-type, which are tumors positive for hormone receptors (estrogen or progesterone receptor). This subtype suggests a response to endocrine therapy. HER2-type, which are positive for over-expression of the HER2 receptor. ER and PR can be positive or negative. This subtype receives targeted therapy.
It is immunologically typically triple-negative, with negative estrogen receptors (ER), negative progesterone receptors (PR), and negative HER2/neu receptors. [3] There are also medullary breast carcinomas that are found to be estrogen receptors (ER) and/or progesterone receptor (PR) positive, making diagnosis less straightforward.
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