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Osteocytes are mechanosensor cells that control the activity of osteoblasts and osteoclasts [16] within a basic multicellular unit (BMU), a temporary anatomic structure where bone remodeling occurs. [17] Osteocytes generate an inhibitory signal that is passed through their cell processes to osteoblasts for recruitment to enable bone formation. [18]
A bone is a rigid organ [1] that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility.
Diagram of a typical long bone showing both compact (cortical) and cancellous (spongy) bone. Osteons on cross-section of a bone. In osteology, the osteon or haversian system (/ h ə ˈ v ɜːr. ʒ ən /; named for Clopton Havers) is the fundamental functional unit of much compact bone.
In an ordinary microscopic section, viewed by transmitted light, they appear as fusiform opaque spots. Each lacuna is occupied during life by a branched cell, termed an osteocyte, bone-cell or bone-corpuscle. Lacunae are connected to one another by small canals called canaliculi. A lacuna never contains more than one osteocyte.
The hollow tubular structure of bones provide considerable resistance against compression while staying lightweight. Most cells in bones are osteoblasts, osteoclasts, or osteocytes. [13] Bone tissue is a type of dense connective tissue, a type of mineralized tissue that gives rigidity and a honeycomb-like three
Diameter of canaliculi in human bone is approximately 200 to 900 nm. [1] In bovine tibia diameter of canaliculi was found to vary from 155 to 844 nm (average 426 nm). [ 2 ] In mice humeri it varies from 80 to 710 nm (average 259 nm), while diameter of osteocytic processes varies from 50 to 410 nm (average 104 nm).
Diagram of a typical long bone showing both cortical (compact) and cancellous (spongy) bone. Haversian canals [i] (sometimes canals of Havers, osteonic canals or central canals) are a series of microscopic tubes in the outermost region of bone called cortical bone. They allow blood vessels and nerves to travel through them to supply the osteocytes.
Diagram of the different types of soft tissue in the body. The body consists of many different types of tissue, defined as cells that act with a specialised function. [8] The study of tissues is called histology and is often done with a microscope. The body consists of four main types of tissues.