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Speedball, powerball, or over and under [1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl. A speedball may be taken intravenously or by nasal insufflation. [2]
[4] [5] [6] Many people also use prescribed and controlled depressants such as opioids, opiates, and benzodiazepines. [2] What controlled substances are considered generally unlawful to possess varies by country, but usually includes cannabis, cocaine, opioids, MDMA, amphetamine, methamphetamine, psychedelics, benzodiazepines, and barbiturates.
The motivation behind its exclusion from the CSA was that under the CSA, all optical isomers of listed Schedule II opiates are automatically Schedule II substances. Since dextromethorphan is an optical isomer of the Schedule II opiate levomethorphan (but does not act like an opiate), an exemption was necessary to keep it an uncontrolled substance.
Naloxone is an over-the-counter nasal-spray medication that can save an overdose victim by rapidly reversing the effects of fentanyl, heroin and other opioids. Doctors urge all people ...
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic.It is 30 to 50 times more potent than heroin and 100 times more potent than morphine; [11] its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries.
Some believe that heroin produces more euphoria than other opioids; one possible explanation is the presence of 6-monoacetylmorphine, a metabolite unique to heroin – although a more likely explanation is the rapidity of onset. While other opioids of recreational use produce only morphine, heroin also leaves 6-MAM, also a psycho-active metabolite.
Fewer than 10% of people with opioid addiction are receiving treatment with medications in the midst of the worst overdose crisis in U.S. history. In December, ...
Anyone using opioids can be at risk for an opioid-related overdose, but people who use drugs after they stopped using drugs for a few days, people who mix opioids with other drugs or alcohol and ...