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The sinoatrial node (SA node) is the primary pacemaker of the heart. It is a region of cardiac muscle on the wall of the upper right atrium near to the superior vena cava entrance. The cells that make up the SA node are specialized cardiomyocytes known as pacemaker cells that can spontaneously generate cardiac action potentials.
A pacemaker, also known as an artificial cardiac pacemaker, is an implanted medical device that generates electrical pulses delivered by electrodes to one or more of the chambers of the heart. Each pulse causes the targeted chamber(s) to contract and pump blood, [ 3 ] thus regulating the function of the electrical conduction system of the heart .
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The cardiac pacemaker is the heart's natural rhythm generator. It employs pacemaker cells that generate electrical impulses, known as cardiac action potentials . These potentials cause the cardiac muscle to contract, and the rate of which these muscles contract determines the heart rate .
Albert Salisbury Hyman (1893 - 1972), a Harvard-trained New York cardiologist, together with his brother Charles, constructed in 1930-1932 an electromechanical device which was one of the earliest artificial pacemakers. The device was reportedly tested on experiment animals and at least one human patient.
Rune Elmqvist (1 December 1906 – 15 December 1996) was a Swedish physician turned engineer who developed the first implantable pacemaker in 1958, working under the direction of Åke Senning, senior physician and cardiac surgeon at the Karolinska University Hospital in Solna, Sweden.
In the early years, the company worked to improve pacemakers' capacity and battery life, and secure the connections among electrodes, pacemakers, and the heart. Since its start, more than 19 million BIOTRONIK devices in over 100 countries have been implanted. [citation needed] In 1976, the company moved to Sieversufer 8 in Berlin-Neukölln.
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