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There are a variety of rare diseases that resemble GH deficiency, including the childhood growth failure, facial appearance, delayed bone age, and low insulin-like growth factor-1 (IGF-1) levels. However, GH testing elicits normal or high levels of GH in the blood, demonstrating that the problem is not due to a deficiency of GH but rather to a ...
Additionally, a high-normal GH level that fails to suppress with administration of glucose is also sufficient for a diagnosis of GH hyper-secretion. [17] Insulin-like growth factor-1 (IGF-1) is an excellent test for evaluation of GH hyper-secretion.
A review of GH levels in 1,360 people worldwide immediately after surgery revealed that 60% had random GH levels below 5 ng/ml. Complications of surgery may include cerebrospinal fluid leaks, meningitis, or damage to the surrounding normal pituitary tissue, requiring lifelong pituitary hormone replacement. [citation needed]
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, ... producing blood levels well above normal ("physiologic").
IGF-1 levels can be analyzed and used by physicians as a screening test for growth hormone deficiency (GHD), [45] acromegaly and gigantism. [46] However, IGF-1 has been shown to be a bad diagnostic screening test for growth hormone deficiency. [47] [48]
Other laboratory abnormalities include GHBP (growth hormone binding protein) levels being low in cases with mutations in the extracellular domain of the GH receptor and normal in cases with mutations in the intracellular domain. Low serum levels of IGFBP are non-diagnostic for LS.
Micromegaly is a term sometimes used to describe a state with abnormal, elevated insulin-like growth factor 1 levels and normal growth hormone levels (with correct suppression during an oral glucose tolerance test).
The test involved measuring the ratio between the levels of growth hormone by a radioreceptor assay (RRA-GH) to the level of growth hormone determined by the established radioimmunoassay (RIA-GH). The study found that the RRA-GH/RIA-GH ratio in NS subjects was normal but significantly below normal (P<0.005) in the Kowarski syndrome patients.