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Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Dosage Fforms Strengths Brand names Manufacturer Oral: Capsules, extended-release: 150 mg (50 mg iron) with Docusate Sodium 100 mg* Ferrous Fumarate with DSS® Timed Capsules: Vita-Rx Tablets, extended-release, film-coated: 150 mg (50 mg iron) with Docusate Sodium 100 mg: Ferro-DSS® Caplets® Time-Caps Ferro-Sequels® Inverness
ATC code A06 Drugs for constipation is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Saline laxatives may alter a patient's fluid and electrolyte balance. Properties. Site of action: small and large intestines; Onset of action: 0.5–3 hours (oral), 2–15 minutes (rectal) Examples: sodium phosphate (and variants), magnesium citrate, magnesium hydroxide (milk of magnesia), and magnesium sulfate (Epsom salt) [3]
Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Constipation is more concerning when there is weight loss or anemia, blood is present in the stool, there is a history of inflammatory bowel disease or colon cancer in a person's family, or it is of new onset in someone who is older. [12] Treatment of constipation depends on the underlying cause and the duration that it has been present. [4]
Labeled on the front as containing docusate calcium: GeriCare (they also make versions containing docusate sodium), Rugby. It appears that docusate sodium and docusate calcium are interchangeable. --Marc Kupper|talk 22:36, 12 November 2018 (UTC) Docusate needs to be combined with a positive ion. This can be sodium, calcium, or potassium.
Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It takes 12–24 hours to work, since it works in the colon. [3] Abdominal cramps and diarrhea are normal effects of picosulfate and should be expected.
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