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A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout, and nail fungus. These drugs disrupt microtubules , which are structures that pull the chromosomes apart when a cell divides.
Early Mitotic Inhibitor 1 (EMI1) is an important cell cycle regulator which ensures timely mitotic entry by primarily inhibiting Anaphase-Promoting Complex/Cyclosome (APC/C) activity. This protein is present in many organisms including Xenopus, Zebrafish, Drosophila (homologous protein: Rca1), and Humans (also often known as F-box only protein ...
Pages in category "Mitotic inhibitors" The following 32 pages are in this category, out of 32 total. This list may not reflect recent changes. ...
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.
3832 16551 Ensembl ENSG00000138160 ENSMUSG00000012443 UniProt P52732 Q6P9P6 RefSeq (mRNA) NM_004523 NM_010615 RefSeq (protein) NP_004514 NP_034745 Location (UCSC) Chr 10: 92.57 – 92.66 Mb Chr 19: 37.36 – 37.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene ...
A mitotic inhibitor (colchicine, colcemid) is then added to the culture. This stops cell division at mitosis which allows an increased yield of mitotic cells for analysis. The cells are then centrifuged and media and mitotic inhibitor are removed, and replaced with a hypotonic solution.
Reversine is a potent inhibitor of the mitotic kinase Mps1 [4] and it is widely used to study the process of chromosome segregation. References
A new approach to inhibiting cancer growth that shows great promise for structure-based drug development is targeting enzymes central to cellular mitosis. [4] Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have gained a great deal of attention as possible anticancer drug targets.