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Modafinil is generally well-tolerated but can have potential risks and side effects. Common adverse effects of modafinil, experienced by less than 10% of users, include headaches, nausea, and reduced appetite. [93] [94] [20] Anxiety, insomnia, dizziness, diarrhea, and rhinitis are also reported in 5% to 10% of users. [20]
Meta-analytic evidence showed that add-on modafinil and armodafinil were more effective than placebo on response to treatment, clinical remission, and reduction in depressive symptoms, with only minor side effects, but the effect sizes are small and the quality of evidence has to be considered low, limiting the clinical relevance of current ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 28 January 2025. American multinational home improvement supplies retailing company The Home Depot, Inc. An aerial view of a Home Depot in Onalaska, Wisconsin Company type Public Traded as NYSE: HD DJIA component S&P 100 component S&P 500 component Industry Retail (home improvement) Founded February 6 ...
Chemical structure of modafinil.. This page lists chemical compounds similar to modafinil, known as modafinil analogues and derivatives.These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way (atypical dopamine reuptake inhibitor or DRI).
In the U.S. military, go pills and no-go pills refers to stimulant medications meant to increase wakefulness and hypnotic medications taken to ensure adequate rest in preparation for upcoming tasks. As of November 2012, medications approved as no-go pills by the U.S. Air Force for aircrew and AFSOC [ 1 ] forces include:
Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones.
It is widely used but "has intolerable side effects at high doses (including cardiovascular), and it is generally not efficient enough for patients with hypersomnia or narcolepsy." [ 20 ] Although it is commonly used by people with IH or narcolepsy, many people with these disorders report that it has only limited benefit on their sleepiness.
[7] [9] [4] Reproductive warnings have also been issued for men using the drug. [10] The United States Food and Drug Administration has indicated a black box warning given the frequency and severity of the side effects and teratogenicity. [4] Additionally, there is also a black box warning due to risk of hepatotoxicity and pancreatitis. [11]