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According to reviews, it is thought that senolytics can be administered intermittently while being as effective as continuous administration. This could be an advantage of senolytic drugs and decrease adverse effects, for instance circumventing potential off-target effects. [6] [12] [13] [14]
Senotherapeutic's refers to therapeutic agents/strategies that specifically target cellular senescence. [1] Senotherapeutic's include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells [2] and agents that inhibit the pro-inflammatory senescent secretome. [3]
During June 2005, David Gobel, CEO and co-founder of the Methuselah Foundation with de Grey, offered Technology Review $20,000 to fund a prize competition to publicly clarify the viability of the SENS approach. In July 2005, Jason Pontin announced a $20,000 prize, funded 50/50 by Methuselah Foundation and MIT Technology Review. The contest was ...
This page was last edited on 1 September 2023, at 18:37 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Cell growth plays a crucial role in cell proliferation, regulating cellular homeostasis and cell cycle progression through dynamic changes in cell size. [1] And like DNA damage, it can promote senescence by triggering a prolonged cell cycle arrest. [5]
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The term qualia derives from the Latin neuter plural form (qualia) of the Latin adjective quālis (Latin pronunciation: [ˈkʷaːlɪs]) meaning "of what sort" or "of what kind" in relation to a specific instance, such as "what it is like to taste a specific apple — this particular apple now".
The concept of absent qualia is one of two major functionalist objections to the existence of qualia, the other being the inverted spectrum hypothesis. Qualia is a philosophical term used to refer to an individual's subjective experience, that is to say, the way something feels to that individual at that particular moment.
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