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Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier into the brain.This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
A blood clot that reaches your brain can cause a stroke. Symptoms of a stroke include sudden: Numbness or weakness, often on one side of your body or face. Confusion. Trouble seeing in one or both ...
Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyribonucleic acid (DNA) are nucleic acids.
An arterial embolism is caused by one or more emboli getting stuck in an artery and blocking blood flow, causing ischemia, possibly resulting in infarction with tissue death . [2] Individuals with arterial thrombosis or embolism often develop collateral circulation to compensate for the loss of arterial flow.
For instance, for treatment of neurodegenerative disorders, molecules for a prospective gene silencing therapy must be delivered to the brain. The blood–brain barrier makes it difficult to deliver molecules into the brain through the bloodstream by preventing the passage of the majority of molecules that are injected or absorbed into the blood.
An embolism is the lodging of an embolus, a blockage-causing piece of material, inside a blood vessel. [1] The embolus may be a blood clot , a fat globule (fat embolism), a bubble of air or other gas (gas embolism), amniotic fluid (amniotic fluid embolism), or foreign material.
Cavernous sinus thrombosis (CST) is the formation of a blood clot within the cavernous sinus, a cavity at the base of the brain which drains deoxygenated blood from the brain back to the heart. This is a rare disorder and can be of two types–septic cavernous thrombosis and aseptic cavernous thrombosis. [ 1 ]
Acute blockage (embolism) of a blood vessel by a thrombus that has detached from its place of formation (on the wall of a vessel) and entered the circulating blood. As a result of this blockage, blood flow in the vessel stops—a condition called thromboembolism. [1] Thromboembolism is a condition in which a blood clot breaks off from its ...