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Since these CTs or C-LTMRs are non-peptidergic, immuno-labelling was a challenge. However, in combination with RNA-seq data and genetically modified mouse models, several labeling markers, i.e. VGLUT3, [6] TAFA4, [7] CaV3.2, [8] CaV3.3 [9] and GINIP [10] have been discovered to visualize C-LTMRs using double staining methods in combination with tyrosine hydroxylase (TH).
Low-threshold calcium spikes have been described in neurons from a variety of brain nuclei, including the thalamic relay, medial pontine reticular formation, lateral habenula, septum, deep cerebellar nuclei, CA1-CA3 of the hippocampus, association cortex, paraventricular and preoptic nuclei of the hypothalamus, dorsal raphe, globus pallidus ...
The Apgar score is a quick way for health professionals to evaluate the health of all newborns at 1 and 5 minutes after birth and in response to resuscitation. [1] It was originally developed in 1952 by an anesthesiologist at Columbia University, Virginia Apgar, to address the need for a standardized way to evaluate infants shortly after birth.
Over the course of its five revisions (the final two co-authored with her daughter Ruth Kenyon Russell) her advice moved from emphasizing rigid schedules to encouraging "on-demand" scheduling based on the child. [4] The child's healthy emotional development was emphasized, as was the importance of the pre- and postnatal health of the mother. [4 ...
According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). [1]
For example, figure 1 depicts the localized nature and the graded potential nature of these subthreshold membrane potential oscillations, also giving a visual representation of their placement on an action potential graph, comparing subthreshold oscillations versus a fire above the threshold. In some types of neurons, the membrane potential can ...
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