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77782 Ensembl ENSG00000051341 ENSMUSG00000034206 UniProt O75417 Q8CGS6 RefSeq (mRNA) NM_199420 NM_006596 NM_001159369 NM_029977 RefSeq (protein) NP_955452 NP_001152841 NP_084253 Location (UCSC) Chr 3: 121.43 – 121.55 Mb Chr 16: 36.83 – 36.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene. This ...
Microhomology-mediated end joining (MMEJ), also known as alternative nonhomologous end-joining (Alt-NHEJ) is one of the pathways for repairing double-strand breaks in DNA. As reviewed by McVey and Lee, [1] the foremost distinguishing property of MMEJ is the use of microhomologous sequences during the alignment of broken ends before joining, thereby resulting in deletions flanking the original ...
ADP-ribose polymers, either free or PARP1 bound, are able to inhibit DNA methyltransferase activity at CpG sites. [20] Thus, CTCF is involved in the cross-talk between poly(ADP-ribosyl)ation and DNA methylation, an important epigenetic regulatory factor. [19]
[7] [8] NHEJ is the main pathway in higher eukaryotes for repair of DNA DSBs. Chromosomal DSBs are the most severe type of DNA damage. During NHEJ, duplexes generated by the alignment of broken DNA ends usually contain small gaps that need to be filled in by a DNA polymerase. DNA polymerase lambda can perform this function. [9]
Shared primase-binding peptide in archaeal PolD and eukaryotic Polα [1] DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2. [2]
Incomplete DNA synthesis and DNA strand breaks are both potential sources of genomic instability. An arsenal of DNA repair mechanisms exists to repair various forms of damaged DNA and minimize genomic instability. Most DNA repair mechanisms require an intact DNA strand as template to fix the damaged strand.
Since DNA polymerase requires a free 3' OH group for initiation of synthesis, it can synthesize in only one direction by extending the 3' end of the preexisting nucleotide chain. Hence, DNA polymerase moves along the template strand in a 3'–5' direction, and the daughter strand is formed in a 5'–3' direction.
RNA and DNA secondary structure prediction by dynamic programming algorithms such as RNAfold [36] and by machine learning models such as SPOT-RNA, [37] MXfold2 [38] provides the opportunity to assess the ability of sequences in the primary library to fold into complex structures, allowing for the selection of only the most promising sequences ...