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Some studies have shown a reasonably characteristic pattern of muscle involvement on whole-body muscle MRI in LAMA2-MD patients. [19] [20] This relates to muscles or group of muscles involvement versus sparing. For example, sparing of the gracilis, sartorius muscles, [20] and the adductor longus muscle [19] [21] has been linked to LAMA2-MD.
The muscle protein, dystrophin, is in most muscle cells and works to strengthen the muscle fibers and protect them from injury as muscles contract and relax. [3] It links the muscle membrane to the thin muscular filaments within the cell. Dystrophin is an integral part of the muscular structure.
Extraocular muscles are shown in this image of the left eye (lateral view). Click on the structures for more information. Click on the structures for more information. In terms of the signs (and symptoms) of oculopharyngeal muscular dystrophy would be consistent with the following: [ 2 ] [ 6 ]
By definition, all limb girdle muscular dystrophies (LGMD) cause progressive proximal weakness, [3] meaning weakness of the muscles on or close to the torso that worsens over time. Explicitly, LGMD preferentially affects muscles of the hip girdle, thigh, shoulder girdle, and/or upper arm. [8] [6] The muscle weakness is generally symmetric. [11]
Stiff-person syndrome is a rare autoimmune neurological disorder that causes muscle stiffness and spasms, limiting mobility and causing other symptoms like double vision and slurred speech ...
Activation of trigger points may be caused by a number of factors, including acute or chronic muscle overload, activation by other trigger points (key/satellite, primary/secondary), disease, psychological distress (via systemic inflammation), homeostatic imbalances, direct trauma to the region, collision trauma (such as a car crash which stresses many muscles and causes instant trigger points ...
Myotonia congenita is a congenital neuromuscular channelopathy that affects skeletal muscles (muscles used for movement). It is a genetic disorder.The hallmark of the disease is the failure of initiated contraction to terminate, often referred to as delayed relaxation of the muscles and rigidity. [1]
Medically unexplained physical symptoms (MUPS or MUS) are symptoms for which a treating physician or other healthcare providers have found no medical cause, or whose cause remains contested. [1] In its strictest sense, the term simply means that the cause for the symptoms is unknown or disputed—there is no scientific consensus .
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