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Tandem repeats can occur through different mechanisms. For example, slipped strand mispairing, (also known as replication slippage), is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases.
In addition to occurring during DNA replication, trinucleotide repeat expansion can also occur during DNA repair. [4] When a DNA trinucleotide repeat sequence is damaged, it may be repaired by processes such as homologous recombination, non-homologous end joining, mismatch repair or base excision repair.
Repeated sequences (also known as repetitive elements, repeating units or repeats) are short or long patterns that occur in multiple copies throughout the genome.In many organisms, a significant fraction of the genomic DNA is repetitive, with over two-thirds of the sequence consisting of repetitive elements in humans. [1]
Recurrent evolution also referred to as repeated [1] [2] or replicated [3] evolution is the repeated evolution of a particular trait, character, or mutation. [4] Most evolution is the result of drift, often interpreted as the random chance of some alleles being passed down to the next generation and others not.
These mutations, typically short sequences repeated many times, give rise to numerous known diseases, including the trinucleotide repeat disorders. Robert I. Richards and Grant R. Sutherland called these phenomena, in the framework of dynamical genetics, dynamic mutations. Triplet expansion is caused by slippage during DNA replication. Due to ...
Slipped strand mispairing (SSM, also known as replication slippage) is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases. Slipped strand mispairing is one explanation for the origin and evolution of repetitive DNA sequences. [1]
Mutation can be more accurately defined as any non-combinatorial change in phenotype that is able to be consistently inherited from parent to offspring over generations. [1] Mutations can be attributed to many factors and come in numerous different forms, however they can mostly be attributed to mistakes that occur during DNA replication or ...
The chromosomes of archaea and eukaryotes can have multiple origins of replication, and so their chromosomes may consist of several replicons [citation needed]. The concept of the replicon was formulated in 1963 by François Jacob, Sydney Brenner, and Jacques Cuzin as a part of their replicon model for replication initiation. According to the ...