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Red: notochord; Magenta: axochord; Green: nerve chord; Blue: epidermis; Yellow: mesoderm. The notochord is an elastic, rod-like structure found in chordates. In chordate vertebrates the notochord is an embryonic structure that disintegrates, as the vertebrae develop, to become the nucleus pulposus in the intervertebral discs of the vertebral ...
The nucleus pulposus of the disc functions to distribute hydraulic pressure in all directions within each intervertebral disc under compressive loads. The nucleus pulposus consists of large vacuolated notochord cells, small chondrocyte-like cells, collagen fibrils, and aggrecan , a proteoglycan that aggregates by binding to hyaluronan .
The notochord will form the nucleus pulposus of intervertebral discs. There is some discussion as to whether these cells contributed from the notochord are replaced by others from the adjacent mesoderm. It gives rise to the notochordal process, which later becomes the notochord.
The notochord disappears in the sclerotome (vertebral body) segments but persists in the region of the intervertebral discs as the nucleus pulposus. The nucleus pulposus and the fibers of the anulus fibrosus make up the intervertebral disc. The primary curves (thoracic and sacral curvatures) form during fetal development.
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Spinal disc herniation, more commonly called a slipped disc, is the result of a tear in the outer ring (anulus fibrosus) of the intervertebral disc, which lets some of the soft gel-like material, the nucleus pulposus, bulge out in a hernia. This may be treated by a minimally-invasive endoscopic procedure called Tessys method.
Complete coverage of the music industry's 67th Grammy Awards taking place on January 31, 2025.