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Curve of the Michaelis–Menten equation labelled in accordance with IUBMB recommendations. In biochemistry, Michaelis–Menten kinetics, named after Leonor Michaelis and Maud Menten, is the simplest case of enzyme kinetics, applied to enzyme-catalysed reactions of one substrate and one product.
Reversible Michaelis–Menten kinetics, using the reversible form of the Michaelis–Menten equation, is therefore important when developing computer models of cellular processes involving enzymes. In enzyme kinetics, the Michaelis–Menten kinetics kinetic rate law that describes the conversion of one substrate to one product, is often ...
This is produced by taking the reciprocal of both sides of the Michaelis–Menten equation. As shown on the right, this is a linear form of the Michaelis–Menten equation and produces a straight line with the equation y = mx + c with a y-intercept equivalent to 1/V max and an x-intercept of the graph representing −1/K M.
This second assumption is compatible with all physically reasonable kinetics, including mass action, Michaelis–Menten and Hill kinetics. Sometimes further assumptions are made about reaction rates, e.g. that all reactions obey mass action kinetics. Other assumptions include mass balance, constant temperature, constant pressure, spatially ...
A plot depicting the initial reaction rate versus substrate concentration as modeled by the Michaelis-Menten equation (solid line) and the Haldane equation for substrate inhibition (dotted line). One of the most well known equations to describe single-substrate enzyme kinetics is the Michaelis-Menten equation.
When n=1, we obtain a model that can be modeled by Michaelis–Menten kinetics, [11] in which = =, the Michaelis–Menten constant. The Hill coefficient can be calculated approximately in terms of the cooperativity index of Taketa and Pogell [12] as follows: [13]
The best known plots of the Michaelis–Menten equation, including the double-reciprocal plot of / against /, [2] the Hanes plot of / against , [3] and the Eadie–Hofstee plot [4] [5] of against / are all plots in observation space, with each observation represented by a point, and the parameters determined from the slope and intercepts of the lines that result.
The Michaelis–Menten equation assumes equilibrium, while the Briggs-Haldane equation assumes a steady state. 81.191.81.174 18:14, 7 December 2022 (UTC) The mechanism proposed by Michaelis and Menten assumed equilibrium, yes, but today nearly everyone takes the Michaelis–Menten equation to be the form derived by Briggs and Haldane.