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A syrette is a single-use device for injecting liquid through a needle. It is similar to a syringe except that it has a sealed squeeze tube instead of a rigid tube and piston . It was developed by the pharmaceutical manufacturer E.R. Squibb & Sons (eventually merged into the current day Bristol-Myers Squibb ) just prior to World War II (WWII).
Animal and human studies and clinical experience back up the contention that morphine is one of the most euphoric drugs known, and via all but the IV route heroin and morphine cannot be distinguished according to studies because heroin is a prodrug for the delivery of systemic morphine.
Laudanum was historically used to treat a variety of conditions, but its principal use was as a pain medication and cough suppressant. Until the early 20th century, laudanum was sold without a prescription and was a constituent of many patent medicines .
Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time."
Dihydromorphine acts as an agonist at the μ-opioid with a K i value of 2.5 nM compared to 4.9 nM of morphine, δ-opioid with a K i value of 137 nM compared to 273 nM of morphine and κ-opioid with a K i value of 223 nM compared to 227 nM of morphine. Dihydromorphine is therefore slightly more μ-selective than morphine.
Federal authorities say a Minnesota pharmacist took morphine from the “stock bottle” meant to fulfill patient prescriptions and replaced the missing liquid with water.. In doing so, the 42 ...
Brompton cocktail, sometimes called Brompton mixture or Brompton's cocktail, was an elixir meant for use as a pain suppressant dosed for prophylaxis.Made from morphine or diacetylmorphine (heroin), cocaine, highly pure ethyl alcohol (some recipes specify gin), and sometimes with chlorpromazine (Thorazine) to counteract nausea, it was given to terminally ill individuals (especially cancer ...
Morphine-N-oxide (genomorphine) is an active opioid metabolite of morphine. Morphine itself, in trials with rats, is 11–22 times more potent than morphine- N -oxide subcutaneously and 39–89 times more potent intraperitoneally .